Effect of general anesthetics on IOP in elevated IOP mouse model
نویسندگان
چکیده
منابع مشابه
Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction.
PURPOSE To determine the effect of several common general anesthetics on intraocular pressure (IOP) after experimental aqueous outflow obstruction in the rat. METHODS A single episcleral vein injection of hypertonic saline was used to sclerose aqueous humor outflow pathways and produce elevated IOP in Brown Norway rats. Animals were housed in either standard lighting or a constant low-level l...
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Intraocular pressure (IOP) is the primary risk factor for developing glaucoma, yet little is known about the contribution of genomic background to IOP regulation. The present study leverages an array of systems genetics tools to study genomic factors modulating normal IOP in the mouse. The BXD recombinant inbred (RI) strain set was used to identify genomic loci modulating IOP. We measured the I...
متن کاملEffect of repeated IOP challenge on rat retinal function.
PURPOSE To characterize the effect of repeated brief intraocular pressure (IOP) elevations and the effect of IOP fluctuation on retinal function. METHODS The effects of one, two, and four episodes (70 mm Hg, 15 minutes) are compared by defining the time course of functional recovery after insults. The effect of IOP variation is considered by comparing a constant with a varying insult, keeping...
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Glaucoma is a leading cause of blindness worldwide, and is characterized by progressive retinal ganglion cell (RGC) death. An experimental model of glaucoma has been established by elevating the intraocular pressure (IOP) via microbead occlusion of ocular fluid outflow in mice. Studies in this model have found visual dysfunction that varied with adaptational state, occurred before anatomical ch...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2011
ISSN: 0014-4835
DOI: 10.1016/j.exer.2011.03.016